منابع مشابه
The enzymatic function of tafazzin.
Tafazzin is a putative enzyme that is involved in cardiolipin metabolism, it may carry mutations responsible for Barth syndrome. To identify the biochemical reaction catalyzed by tafazzin, we expressed the full-length isoform of Drosophila melanogaster tafazzin in a baculovirus-Sf9 insect cell system. Tafazzin expression induced a new enzymatic function in Sf9 cell mitochondria, namely 1-palmit...
متن کاملDrosophila tafazzin mutants have impaired exercise capacity
Cardiolipin (CL) is a mitochondrial phospholipid that helps maintain normal structure of the inner mitochondrial membrane and stabilize the protein complexes of the electron transport chain to promote efficient ATP synthesis. Tafazzin, an acyl-transferase, is required for synthesis of the mature form of CL. Mutations in the tafazzin (TAZ) gene are associated with a human disorder known as Barth...
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BAR domain proteins contribute to membrane deformation in diverse cellular processes. The inverted-BAR (I-BAR) protein IRSp53, for instance, is found on the inner leaflet of the tubular membrane of filopodia; however its role in the formation of these structures is incompletely understood. Here we develop an original assay in which proteins are encapsulated in giant unilamellar vesicles connect...
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Sustained neurotransmitter release at synapses during high-frequency synaptic activity involves the mobilization of synaptic vesicles (SVs) from the tightly clustered reserve pool (RP). Synapsin I (Syn I), a brain-specific peripheral membrane protein that undergoes activity-dependent cycles of SV association and dissociation, is implicated in RP organization via its ability to cluster SVs. Alth...
متن کاملSomesthetic senses.
This is a review of recent advances in our understanding of the sensory modalities of touch, temperature sensitivity, and pain. Most of the research described is psychophysical or perceptual in nature, but physiological and imaging studies are included when they sharpen issues or reveal underlying mechanisms. Coverage of touch research comprises the subjects of acuity, vibrotaction and texture ...
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ژورنال
عنوان ژورنال: Nature Chemical Biology
سال: 2012
ISSN: 1552-4450,1552-4469
DOI: 10.1038/nchembio.1068